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Press Release:

Mannatech Announces Publication of Ambrotose Product Prebiotic Study

Scientists at Ghent University explore bacterial effects on digestive health

(Coppell, Texas) October 10, 2012 - Mannatech, Incorporated (NASDAQ: MTEX), the leading innovator and provider of naturally sourced supplements based on Real Food Technology® solutions, announced today the publication of a study that employed state-of-the-art technology to further explore the prebiotic effects of its Ambrotose® products. Performed by scientists at The Laboratory of Microbial Ecology and Technology (LabMET) at Ghent University (Universiteit Gent) in Ghent, Belgium, the study was published in the Antonie van Leeuwenhoek Journal of Microbiology.¹

"As The Economist magazine's recent cover story, "Microbes Maketh Man", made clear, the bacteria that populate the human body — particularly those in the gut — have an enormous impact on our health," commented Dr. Robert Sinnott, Chief Science Officer and CEO at Mannatech, Incorporated. "LabMET scientists have been leaders in the development of tools to better assess human gut bacterial populations. This is the first study to apply 16sRNA genes-based pyrosequencing in a Simulator of the Human Intestinal Microbial Ecosystem (SHIME) study."

The pyrosequencing technique allowed LabMET scientists to explore more deeply findings from a previous study published by Ghent University scientists, which showed that Advanced Ambrotose powder exhibited prebiotic effects along the entire colon.²

Scientists at LabMET are devoted to investigating the optimal management of microbial resources, with the goal of developing novel products and processes that can improve the environment or human health in the most sustainable way.

Reference List

¹Marzorati M, Maignien L, Verhelst A et al. Barcoded pyrosequencing analysis of the microbial community in a simulator of the human gastrointestinal tract showed a colon region-specific microbiota modulation for two plant-derived polysaccharide blends. Antonie Van Leeuwenhoek 2012. Published online October 5, 2012.

²Marzorati M, Verhelst A, Luta G et al. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol 2010;139:168-76.

Science - Probiotic Effect of Ambrotose Complex

Pre-clinical studies suggest that Ambrotose products exert immune system¹and prebiotic effects, and support gastrointestinal health.* Prebiotic effects, assessed using a state-of-the-art simulation of the human GI tract (SHIME), indicate that Ambrotose products are bifidogenic and may enhance species belonging to Bacteroidetes, a phylum recently associated with body-weight management.²*

In an eight-week, open-label human clinical trial of healthy adults investigating the ability of Advanced Ambrotose powder to impact cellular communication, product intake affected serum glycosylation profiles, significantly increasing levels of disialylated N-linked glycans in human plasma.³*

Three independent placebo-controlled trials of more than 150 healthy adults indicate that intake of Ambrotose powder can also support cognitive health.*

In a randomized, double-blind, 12-week placebo-controlled trial, Ambrotose complex significantly improved memory (as measured by the Rey Auditory-Verbal Learning Test) and decreased anger-hostility, improved mood (as measured by the Profile of Mood States Questionnaire).* Researchers in Mannatech's laboratory and at academic institutions worldwide are continuing to explore the beneficial health effects of Ambrotose products.

  

REFERENCES Ramberg JE, Nelson ED, Sinnott RA. Immunomodulatory dietary polysaccharides: a systematic review of the literature. Nutr J 2010;9:1-60. Marzorati M, Verhelst A, Luta G et al. In vitro modulation of the human gastrointestinal microbial community by plant-derived polysaccharide-rich dietary supplements. Int J Food Microbiol 2010;139:168-76. Alavi A, Fraser W, Tarelli E, Bland M, Axford J. An open-label dosing study to evaluate the safety and effects of a dietary plant derived polysaccharide supplement on the N-glycosylation status of serum glycoproteins in healthy subjects. Eur J Clin Nutr 2011;1-9. Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: A randomized controlled trial. Dev Neuropsych 2010;35:66-80.

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