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Glyconutritionals Revisited-2015

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Glycobiology, Glycoproteins — Complex carbohydrates,
Glycans and Glyconutrients

Posted: By Mannatech in All About Mannatech, 03 Dec 2013 12:35 PM PST

Uth Skin Rejuvenation Crème — utilizes the science of of glycans

From glycobiology, the science that is uncovering the way our bodies work at the cellular level, comes the secret to more youthful-looking skin.

Otherwise known as complex sugars, some glycans appear to help our skin cells communicate with each other. These glycans may serve as messengers; helping cells in each layer of the skin "talk" to each other as they perform important tasks related to the structure and function of skin.

A huge array of diverse glycans cover almost every cell in our bodies. They are part of a network that contributes to the ability of cells to communicate their needs with each other. Some appear to serve as biological keys that activate a chain reaction of signals between skin cells that are necessary for the production of the structural components within the matrix — the layer of skin underneath the top layer that nourishes and protects our skin.

What's so exciting is that our Uth Skin Rejuvenation Crème has been formulated to deliver naturally sourced glycans, featuring Manapol® powder, to the skin matrix to help spark our skin's natural ability to strengthen itself.

Uth Skin Rejuvenation Crème explained by Jackie Pack
Please fast forward to 15:00

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Glyconutrients 101: Part One
There's been a lot of talk lately about glycobiology — in the news, mentions on blogs, etc. And now, the National Academy of Sciences* has emphasized its importance in a recent report, which is a very big deal.

Glycobiology, Glyconutrients, Glyco WHAT?
Glycobiology is the study of everything related to the structure, biosynthesis and biology of sugars and saccharides.

If you've heard the word "glycobiology" before, then it's likely you are somewhat technically minded. It's certainly not a common term that you'd expect to hear at swap meets or cocktail parties.

The term
You see, glycobiology actually undergirds much of what you (hopefully) put in your mouth: fruits and vegetables. So, perhaps you should know about it. In fact, to simplify things, let's look at the word itself.

If you break it down, glyco is from the Greek word "glukus," meaning "sweet." Biology comes from the Greek root, bio, which means "life" and logy from the Greek suffix "logy," which means "study."

In other words, it's the study of biological sugars. Put another way, it's the study of the sweet language of life.

However, to really understand how glycobiology is important for us humans, you need a context. And that context is your body; specifically, your cells.

Do You Speak Cellular?
You may not. But your body does. Inside, you have trillions of cells that are constantly communicating with each other. These cells are multi-taskers — they take in nutrition, eliminate toxins, defend the body from intruders and repair damage in the body. They must communicate with one another and work as a team to promote good health. When your cells talk, your body listens. It flourishes. And you simply thrive.

Modern science, as in the aforementioned National Academy of Sciences, is uncovering more evidence all the time supporting the concept that certain sugars control and influence many, many aspect of our cellular processes. These are fundamental sugars the body needs at its most foundational level to maintain optimal wellness.

More than 200 sugars can be found in nature. Some dietary sugars are absorbed by the body and burned as fuel. But, according to Harper's Biochemistry, a textbook used in medical schools worldwide, eight specific sugars comprise the very chains of glycoproteins in our body.

Glyconutritionals Revisited-2015

  • Glucose**
  • Xylose
  • Fucose
  • N-acetylglucosamine
  • Mannose
  • N-acetylgalactosamine
  • Galactose**
  • N-acetylneuraminic Acid

  • -Harper's Biochemistry, 1996 ed.

    **Only two out of eight of these sugars are commonly found in our modern diets.

    When sugars are missing from the glycoprotein structures, our cells cannot function normally. They can't communicate or perform other critical functions. Sugars, you might ask? Yes, sugars! They are also called saccharides, but we're not talking about the sugar you put on your cereal or in your afternoon tea. That's sucrose, or table sugar. We're talking about plant-derived complex carbohydrates, or polysaccharides, that you won't find at your local Sack 'N Save.

    Where do these polysaccharides come from? Nature. Or, more specifically, natural food sources. However, because we typically don't eat the right kinds of food, many of these sugars may be lacking in our modern diets.

    That's why supplementing with glyconutrients can be so important. Glyconutrients are formulated to help support the proper formation of glycoproteins . . . which may then help cells communicate . . . which, in turn, may allow the immune system and body to function as it should. Because of this, increasing numbers of health care professionals and nutritionists are now recommending glyconutrient supplementation. Hello, Aloe!

    Remember those sugars from nature, many of which can't be found at the store? Well, in the early 1980s, a research team, led by scientist Bill McAnalley, PhD, identified and isolated one of those complex sugars — a long chain of mannose sugars — as a key beneficial ingredient in aloe vera. And so, in 1994, Mannatech introduced the Man-Aloe® complex — a nutritional complex designed to support the proper structure and function of cells.

    Mannatech then recognized the potential benefits of combining this aloe vera gel polysaccharide with other plant-sourced carbohydrates. Continued studies, and a global search for the finest ingredients, led to the creation of the next generation of aloe-vera-based formulations — Ambrotose® complex — in 1996. The name "Ambrotose" was derived from "ambrosia', the food of the gods in Greek mythology.

    But this formulation was and is far from mythological. Prior to Mannatech's development of Ambrotose, science had never before validated a beneficial effect of an aloe vera complex sugar molecule. However, since its inception, Ambrotose technology has received much recognition.

    Ambrotose® — A Missing Link in Human Nutrition

    Ambrotose® complex is the first dietary supplement to combine a standardized blend of plant-sourced glyconutrients. More than 50 patents worldwide have been issued on this breakthrough discovery in health.

    But don't take our word for it; third-party scientific studies prove otherwise.† Let's start once more with some context:

    The Old Theory:
    Scientists once believed that it was not possible to influence the body's production of cell surface sugar structures through dietary intervention.

    Mannatech's Clinical Studies
    Clinical trials or studies are forms of research by experts to determine whether supplements are safe and effective. Mannatech makes a promise of wellness through its products, and much of what Mannatech promises is backed by science. Currently, 17 human clinical trials have been published, 13 of which were double-blind, placebo-controlled studies — the gold standard for product validation. From GlobalCommunications@Mannatech.com 10/29/15

    The New Reality
    New research published in the European Journal of Clinical Nutrition (2008) 65, 648-56 reported that: "For the first time, science has shown that the ingestion of a standardized blend of plant polysaccharides [Ambrotose complex] can induce significant changes in blood glycoprotein structures with no adverse effects."

    This study is one of many studies conducted by highly respected researchers and scientists on the benefits of glyconutrients. Just go to MannatechScience.org where you can read studies showing that Ambrotose® supports improvements in brain function. And that's just the tip of the aloeberg.

    Glyconutrients: Gimmick or Genius?
    Even though the science of glycobiology emerged about 60 years ago and the study of glyconutrients emerged about 20 years ago, and they have achieved scientific milestones, glyconutrients are still slow to appear on the healthcare and nutrition professionals' radar. But that's not uncommon when something is so revolutionary.

    The challenge and, frankly, the resistance that glyconutrients and their value have met from many naysayers reminds me of a famous often-quoted saying of the writer, Jonathan Swift: "When a true genius appears in the world, you may know him by this sign, that dunces are in a confederacy against him."

    Certainly, everyone is entitled to his or her own opinion. If you have heard that glyconutrients is not a valid science, I challenge you to read, think and decide for yourself. I think the genius will be hard to miss.

    † Studies may have been funded, in whole or part, by Mannatech. In some cases, this means that Mannatech donated the product that was studied. Lisa Johnson

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    Glyconutrients 101: Part Two

    In Glyconutrients 101: Part One, we answered the question Glyco WHAT? We looked at ways our cells communicate in our bodies and how glyconutrients may play a very important part in that communication.

    Now let's answer Glyco WHY?
    Here, we will delve a bit more into the fascinating science behind glyconutrients and how the science of glycobiology is the foundation of Mannatech's products.

    World-Class Scientists and Pioneers
    Take Dr. John Rollins, for example, a top-notch medical biologist and a prime example of the caliber of scientific experts who endorse and stand behind our products. For 15 years, Dr. Rollins was a Biotech Patent Examiner at the U.S. Office of Trademarks and Patents in Washington, D.C. During his tenure, he witnessed a wide variety of products come and go, as this is where all new patent applications are sent.

    Dr. Rollins often shares the story of his first encounter with the technology which Mannatech’s Ambrotose® is based on. He was examining a series of patent applications from an inventor, Dr. Bill McAnalley, who claimed he had been able to isolate a particular compound from aloe. He claimed that this compound was a glyconutrient, or complex sugar, that supported the immune system and had the potential to affect cell-to-cell communication. Dr. Rollins says he was “skeptical” when he first heard about it because, at that time, glyconutrients were unheard of.

    However, as Dr. Rollins began to examine the technology a little more, he says, "...it was a goose pimple raising experience for me."

    He goes on to say, "We could see that this discovery really was going against the grain of what scientists were thinking...Now, of course, we understand why a new scientific theory, particularly one as bold and game-changing as this was, received such scrutiny." Mannatech, as a pioneer of glyconutrients, has blazed the trail for a whole new category of nutrition, and we continue to successfully respond to questions and debates.

    "That's simply how science works, and that's simply what pioneers have to face," Dr. Rollins notes.

    Independent Studies
    The benefits of Mannatech products have been validated by numerous clinical studies. Two studies, of particular note, for Ambrotose® complex — our glyconutrient formulation — were conducted by independent researchers from Washington, D.C. and Australia.†

    Both were double-blind, placebo-controlled trials of healthy adults. Results indicated that Ambrotose powder can improve brain function, including visual discrimination, memory and well-being.*

    Another pre-clinical study conducted by scientists at Ghent University and ProDigest, a leading company in gastrointestinal (GI) research, investigated the effects of Ambrotose® complex and Advanced Ambrotose® powder on bacterial populations in the human GI tract.

    "The work done by Dr. Marzorati and his team suggests that Ambrotose products support GI health throughout the entire colon; most prebiotics are thought to only exert such effects in the first portion of the colon."* Robert A. Sinnott, CEO and Chief Science Officer.

    University of Ghent
    University of Ghent.jpg

    The Ghent University study's findings were published in the peer-reviewed International Journal of Food Microbiology

    Mannatech has been a leader in the dietary supplement industry since 1994. Using science, we develop safe, natural and innovative supplements and skin care products designed to be incorporated with a healthy diet and lifestyle. Many of our products are validated and endorsed by leading scientists.

    We support our claims and confirm the quality and efficacy of many of our products through high-quality research collaborations with top-notch scientists around the world. With more than 90 patents worldwide, we've been changing the health and wellness of people just like you for years.

    Something New
    Our latest product, Uth Advanced Skin Matrix Rejuvenation Crème, is quite remarkable.
    The name Uth, pronounced "youth," represents ageless beauty whose time has come.

    Here is how it is formulated to work:
    It is designed to allow you to release your body's natural ability to support beautiful, healthy skin through a new, patented microsphere delivery system that nourishes your skin with youth-inducing ingredients in a time-released pattern. This pattern may support the natural production of skin cells at all levels by delivering naturally sourced glycans, featuring Manapol® Powder .

    As noted above, scientific research suggests that these complex sugars are involved in cell-to-cell communication, an essential part of healthy body function. So, if you would like to support your health, consider supplementing with glyconutrients — inside with our many, scientifically-validated products or outside with Uth Skin Rejuvenation Crème.

    Either way, your cells will thank you...because when your cells talk, your body listens!

    Dr. Rollins is a Mannatech Associate and a frequent speaker at company events.
    *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

    † Studies were at least partially funded by Mannatech. In some cases, this means that Mannatech donated the product that was studied. In other cases, additional funding was provided. Ben Hulet

    From All About Mannarech 2/15/14
    The science of nutritional glycobiology, or as it is called: The Sweet Language of Life.
    Of the 200 sugars that naturally occur in nature, our cells use eight of those, like letters of an alphabet, to create cellular words1:

  • Glucose**
  • Fucose
  • Mannose
  • Galactose**
  • Xylose
  • N-acetylglucosamine
  • N-acetylgalactosamine,
  • and
  • N-acetylneuraminic.

  • - Harper's Biochemistry, 1996. Ed.

    Cell surface sugar structures called glycoproteins are necessary for the proper recognition and functioning of many cells. When sugars are missing from the glycoprotein structures, cells cannot function normally.

    Immune system cells read the cell surface sugar structures on other cells to determine if they're healthy, need repair or need to be destroyed. Likewise, when sugars are missing from glycoproteins on cells, immune system cells may not know whether to ignore, attack or protect them.

    Enter Mannatech's scientific breakthrough, Ambrotose® products.

    They are the first dietary supplements formulated to provide standardized levels of plant-sourced glyconutrients (sugars intended to support cellular communication).

    So Where Do Mannatech's Sugars Come From?

    A key component of Ambrotose products is stabilized acetylated mannans from aloe vera gel. Other healthful plants—brown algae and plant gums — contain saccharides that are much less common in our modern diets than they were in the past.
    Ambrotose® products2 have been validated in scientific studies to:

  • Support Cellular Communication*
  • Improve Cognitive Function*
  • Improve Memory*
  • Improve Concentration*
  • Improve Attentiveness*
  • Improve Mood*
  • Decrease Irritability*
  • Support Immune System Function*
  • Support Digestive System Function*

  • Committee on Assessing the Importance and Impact of Glycomics and Glycosciences.
    Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012.

    2Benefits vary by product. Mannatech funded some of these studies and donated the product for all of them.

    **Only two commonly found in the modern diet.

    *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

    Ambrotose® Improves Memory, New Study Finds

    Feb 13, 2014 03:50 pm

    In a press release issued on Wednesday, February 12th, we were proud to announce the findings of a new study conducted on our Ambrotose® Complex powder by Dr. Talitha Best.

    In the study, 73 healthy, mentally fatigued middle-aged adults who were given Ambrotose Complex demonstrated significant improvements on a battery of tests assessing cognitive function, without having their blood glucose levels affected.

    The study was the third double-blind, placebo-controlled trial to demonstrate increased cognitive function after both a singe serving and long-term intake of Ambrotose. These findings are significant because a large number of older Americans take dietary supplements to support their overall wellness and are seeking to find help with age-related memory problems, but have yet to find a supplement that they believe will help.

    Our Ambrotose® line of products are patented, clinically validated and have been proven safe for consumption for almost 20 years, which makes them a fantastic choice for people who want to get the most out of their golden years.

    Read the Full Press Release and Study

    Some other sources of information on Glycobiology: (note: the opinions expressed on these sites are their own and not neccessarily shared by the owners of wellness777int.com.)

    Transforming Glycoscience by NAS pdf.

    Glycobiology studies

    The National Academies of Sciences - Engineering - Medicine

    New Scientist, 10/02 reported, "'This is going to be the future,' declares biochemist Gerald Hart of Johns Hopkins University in Baltimore. 'We won't understand immunology, neurology, developmental biology or disease until we get a handle on glycobiology.' ... 'If you ask, what is the glycome for a single cell type, it's probably many thousands of times more complex than the genome,' says Ajit Varki, Director of the Glycobiology Research and Training Center at the University of California in San Diego ... Raymond Dwek, Head of the University of Oxford’s Glycobiology Institute, who coined the term "glycobiology" in 1988, says that sugars were often dismissed as unimportant, 'as just decorations on proteins — people didn't know how to deal with them." They could not have been more wrong.

    Another quote:
    The following is a quote from the Institute for Glycomics at Griffith University: "Glycomics is the study of applied biology and chemistry that deals with the structure and function of carbohydrates (sugars). The term glycomics is derived from the chemical prefix for sweetness or a sugar, "glyco', and was formed to follow the naming convention established by genomics (which deals with genes) and proteomics (which deals with proteins)."

    In Chapter 15, Electrolytes play major role in neuron conductivity, I report, "Your body contains a very sophisticated battery to power all of its functions including thought. When you feel "run down," that is exactly what has happened. Your battery is low. Without electrolytes, you could not move, think, or live.

    "Electrolytes are in a gel or liquid of salts that conduct electricity. These salts are made up of certain minerals including calcium, chloride, magnesium, potassium, and sodium ions, which are essential for the flow of electrons and, of course, good human health. Because electrolytes are essential minerals, they cannot be substituted in the diet with anything less. These minerals are absolutely vital." The absence of these minerals results in poor communication and a flawed immune system.— End of quote